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Journal of medicinal chemistry

ISSN 1520-4804· EN

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41.4/100
Journament Score
#4,933
Journament Rank
122
Articles Indexed

About This Journal

Short Name J Med Chem
Abbreviated Name j med chem
ISSN 1520-4804
URL http://pubs.acs.org/journal/jmcmar

Indexings

scopus ncbi ulakbim sci

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Publications Per Year

Articles (122)

2019
Design, Synthesis, and Structure-Activity Relationships of 1,2,3-Triazole Benzenesulfonamides as New Selective Leucine-Zipper and Sterile-α Motif Kinase (ZAK) Inhibitors.
Yang, Jianzhang;Shibu, Marthandam Asokan;Kong, Lulu;Luo, Jinfeng;BadrealamKhan, Farheen;Huang, Yanhui;Tu, Zheng-Chao;Yun, Cai-Hong;Huang, Chih-Yang;Ding, Ke;Lu, Xiaoyun;
507 views DOI Abstract
2000
Novel 1,5-Diphenylpyrazole Nonnucleoside HIV-1 Reverse Transcriptase Inhibitors with Enhanced Activity versus the Delavirdine-Resistant P236L Mutant:  Lead Identification and SAR of 3- and 4-Substituted Derivatives
Genin, Michael J.;Biles, Carolyn;Keiser, Barb J.;Poppe, Susan M.;Swaney, Steven M.;Tarpley, W. Gary;Yagi, Yoshihiko;Romero, Donna L.
Vol. 43 , No. 5 , pp. 1034-1040
466 views DOI Abstract
2019
Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.
Zhu, Xuezhen;Wong, Iris L K;Chan, Kin-Fai;Cui, Jiahua;Law, Man Chun;Chong, Tsz Cheung;Hu, Xuesen;Chow, Larry M C;Chan, Tak Hang;
Vol. 62 , No. 18 , pp. 8578-8608
457 views DOI Abstract
2012
Design, synthesis, and structure-activity correlations of novel dibenzo[b,d]furan, dibenzo[b,d]thiophene, and N-methylcarbazole clubbed 1,2,3-triazoles as potent inhibitors of Mycobacterium tuberculosis.
Patpi, Santhosh Reddy;Pulipati, Lokesh;Yogeeswari, Perumal;Sriram, Dharmarajan;Jain, Nishant;Sridhar, Balasubramanian;Murthy, Ramalinga;Anjana Devi, T;Kalivendi, Shasi Vardhan;Kantevari, Srinivas;
Vol. 55 , No. 8 , pp. 3911-22
438 views DOI Abstract
1993
Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents
Van Aerschot AA;Mamos P;Weyns NJ;Ikeda S;De Clercq E;Herdewijn PA;;
Vol. 36 , No. 20 , pp. -
418 views Abstract
1995
Synthesis and antiviral activity of benzyl-substituted imidazo [1,5-a]-1,3,5-triazine (5,8-diaza-7,9-dideazapurine) derivatives
Golankiewicz B;Januszczyk P;Ikeda S;Balzarini J;De Clercq E;;
Vol. 38 , No. 18 , pp. -
414 views Abstract
2019
Linker Optimization and Therapeutic Evaluation of Phosphatidylserine-Targeting Zinc Dipicolylamine-based Drug Conjugates.
Liu, Yu-Wei;Chen, Yun-Yu;Hsu, Chia-Yu;Chiu, Tai-Yu;Liu, Kuan-Liang;Lo, Chen-Fu;Fang, Ming-Yu;Huang, Yu-Cheng;Yeh, Teng-Kuang;Pak, Koon Y;Gray, Brian D;Hsu, Tsu-An;Huang, Kuan-Hsun;Shih, Chuan;Shia, Kak-Shan;Chen, Chiung-Tong;Tsou, Lun K;
411 views DOI Abstract
2018
Development of Potent Inhibitors of Receptor Tyrosine Kinases by Ligand-Based Drug Design and Target-Biased Phenotypic Screening.
Myers, Samuel H;Temps, Carolin;Houston, Douglas R;Brunton, Valerie G;Unciti-Broceta, Asier;
Vol. 61 , No. 5 , pp. 2104-2110
411 views DOI Abstract
2019
Inhibition Mechanisms of Indoleamine 2,3-Dioxygenase 1 (IDO1).
Röhrig, Ute Friederike;Reynaud, Aline;Majjigapu, Somi Reddy;Vogel, Pierre;Pojer, Florence;Zoete, Vincent;
406 views DOI Abstract
2019
Fragment-Based Discovery of a Qualified Hit Targeting the Latency-Associated Nuclear Antigen of the Oncogenic Kaposi's Sarcoma-Associated Herpesvirus/Human Herpesvirus 8
Kirsch, P.
Vol. 62 , pp. 3924-3939
378 views DOI
2021
Tricyclic Triazoles as σ Receptor Antagonists for Treating Pain.
Díaz, José Luis;Cuevas, Félix;Oliva, Ana I;Font, Daniel;Sarmentero, M Ángeles;Álvarez-Bercedo, Paula;López-Valbuena, José M;Pericàs, Miquel A;Enrech, Raquel;Montero, Ana;Yeste, Sandra;Vidal-Torres, Alba;Álvarez, Inés;Pérez, Pilar;Cendán, Cruz Miguel;Cobos, Enrique J;Vela, José Miguel;Almansa, Carmen;
Vol. 64 , No. 8 , pp. 5157-5170
187 views DOI Abstract
2021
Synthesis of the Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor NB-360.
Rueeger, Heinrich;Lueoend, Rainer;Machauer, Rainer;Veenstra, Siem J;Holzer, Philipp;Hurth, Konstanze;Voegtle, Markus;Frederiksen, Mathias;Rondeau, Jean-Michel;Tintelnot-Blomley, Marina;Jacobson, Laura H;Staufenbiel, Matthias;Laue, Grit;Neumann, Ulf;
Vol. 64 , No. 8 , pp. 4677-4696
181 views DOI Abstract
2021
Discovery of Umibecestat (CNP520): A Potent, Selective, and Efficacious β-Secretase (BACE1) Inhibitor for the Prevention of Alzheimer's Disease.
Machauer, Rainer;Lueoend, Rainer;Hurth, Konstanze;Veenstra, Siem J;Rueeger, Heinrich;Voegtle, Markus;Tintelnot-Blomley, Marina;Rondeau, Jean-Michel;Jacobson, Laura H;Laue, Grit;Beltz, Karen;Neumann, Ulf;
Vol. 64 , No. 20 , pp. 15262-15279
161 views DOI Abstract
2020
Integrating the Impact of Lipophilicity on Potency and Pharmacokinetic Parameters Enables the Use of Diverse Chemical Space during Small Molecule Drug Optimization.
Miller, Randy R;Madeira, Maria;Wood, Harold B;Geissler, Wayne M;Raab, Conrad E;Martin, Iain J;
291 views DOI Abstract
2020
Synthetic Approaches to the New Drugs Approved During 2018.
Flick, Andrew;Leverett, Carolyn A;Ding, Hong Xia;McInturff, Emma L;Fink, Sarah;Helal, Christopher;Deforest, Jacob;Morse, Peter;Mahapatra, Subham;O'Donnell, Christopher J;
318 views DOI Abstract
2020
α-Ketoamides as Broad-Spectrum Inhibitors of Coronavirus and Enterovirus Replication: Structure-Based Design, Synthesis, and Activity Assessment
Zhang, L.
, pp. 0-0
207 views DOI
2020
Structure-based stabilization of non-native protein-protein interactions of coronavirus nucleocapsid proteins in antiviral drug design
Lin, Shan-Meng;Lin, Shih-Chao;Hsu, Jia-Ning;Chang, Chung-ke;Chien, Ching-Ming;Wang, Yong-Sheng;Wu, Hung-Yi;Jeng, U-Ser;Kehn-Hall, Kylene;Hou, Ming-hon
287 views
2020
Erratum: Novel Ligustrazine-Based Analogs of Piperlongumine Potently Suppress Proliferation and Metastasis of Colorectal Cancer Cells in Vitro and in Vivo (Journal of Medicinal Chemistry (2018) 61:5 (1821-1832) DOI: 10.1021/acs.jmedchem.7b01096)
Zou, Y.
, pp. 0-0
236 views DOI
2020
Synthesis and Biological Validation of a Harmine-based, Central Nervous System (CNS)-Avoidant, Selective, Human β-Cell Regenerative Dual-Specificity Tyrosine Phosphorylation-Regulated Kinase A (DYRK1A) Inhibitor.
Kumar, Kunal;Wang, Peng;Wilson, Jessica;Zlatanic, Victor;Berrouet, Cecilia;Khamrui, Susmita;Secor, Cody;Swartz, Ethan;Lazarus, Michael B;Sanchez, Roberto;Stewart, Andrew F;Garcia-Ocana, Adolfo;DeVita, Robert J;
249 views DOI Abstract
2020
Enhanced Activity against Multi-drug Resistant Bacteria through Coapplication of an Analogue of Tachyplesin I and an Inhibitor of the QseC/B Signaling Pathway.
Yu, Rilei;Wang, Jiayi;So, Lok-Yan;Harvey, Peta J;Shi, Juan;Liang, Jiazhen;Dou, Qin;Li, Xiao;Yan, Xiayi;Huang, Yen-Hua;Xu, Qingliang;Kaas, Quentin;Chow, Ho-Yin;Wong, Kwok-Yin;Craik, David J;Zhang, Xiaohua;Jiang, Tao;Wang, Yan;
119 views DOI Abstract
41
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Journament

Overall Quality Score

41.4/100

Tier: Below Average

The Journament Overall Quality Score is a comprehensive metric that evaluates academic journals across multiple dimensions including engagement, accessibility, diversity, innovation, and community impact.

This score helps researchers, institutions, and publishers understand the holistic quality and impact of a journal beyond traditional metrics.

Engagement Score

31.5/100

Measures user interactions, views, citations, and community involvement with this journal's content.

Higher engagement scores indicate that the journal's content is actively being read, cited, and discussed within the academic community.

Accessibility Score

35.0/100

Evaluates how easily researchers can access journal content, including open access availability, ISSN registration, and indexing.

This metric considers factors such as paywalls, open access policies, and availability across different academic databases and search engines.

Diversity Score

30.0/100

Assesses geographic and institutional diversity of authors, editorial board composition, and topic breadth.

A diverse journal publishes work from various geographic regions, institutions, and covers a broad range of topics within its field.

Innovation Score

40.0/100

Evaluates research novelty, interdisciplinary work, and emerging topics based on AI analysis of article abstracts.

This score reflects how much the journal publishes cutting-edge research, explores new methodologies, and bridges different academic disciplines.

Community Impact Score

33.0/100

Measures scholarly contribution and real-world applications of published research.

This metric evaluates how the journal's research translates into practical applications, policy changes, and benefits to society beyond academia.

Timeliness Score

50.0/100

Evaluates recent publication activity, publication frequency, and currency of research topics.

Higher scores indicate consistent publishing schedules and timely coverage of current research trends.

Ethics & Transparency Score

0.0/100

Research Integrity (10% weight)

Assesses COPE standards compliance, ethical considerations in research, transparency in methodologies, and reproducibility practices.

This metric ensures the journal maintains high ethical standards and promotes transparent, trustworthy research.

Content Quality Score

0.0/100

Academic Rigor (20% weight) + Methodology Quality (12%)

Evaluates research methodology soundness, statistical rigor, theoretical framework strength, appropriateness of research methods, data quality, and clarity & readability.

This comprehensive metric ensures published research meets the highest academic standards.

Editorial Diversity Score

0.0/100

Author Diversity + Interdisciplinary Value (8%)

Measures geographic diversity of authors, institutional variety, editorial board composition, and cross-disciplinary connections.

Diverse editorial teams bring varied perspectives and reduce bias in academic publishing.

Publication Regularity Score

0.0/100

Assesses consistency of publication schedule, frequency stability, and predictable output patterns.

Regular publication schedules indicate reliable journal operations and consistent workflow management.

Geographic Reach Score

0.0/100

Evaluates international author representation, global readership distribution, and cross-border research collaboration.

Wide geographic reach indicates global impact and international recognition of the journal's research.