Synthetic Approaches to the New Drugs Approved During 2018.

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ID: 105087
2020
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Abstract
New drugs introduced to the market every year represent privileged structures for particular biological targets. These new chemical entities (NCEs) provide insight into molecular recognition while serving as leads for designing future new drugs. This annual review describes the most likely process-scale synthetic approaches to thirty-nine new chemical entities approved for the first time globally in 2018.
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flick2020syntheticjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Flick, Andrew;Leverett, Carolyn A;Ding, Hong Xia;McInturff, Emma L;Fink, Sarah;Helal, Christopher;Deforest, Jacob;Morse, Peter;Mahapatra, Subham;O'Donnell, Christopher J;
Journal Journal of medicinal chemistry
Year 2020
DOI
10.1021/acs.jmedchem.0c00345
URL
Keywords
biological activity anti-tumor antivirus immune regulation structural modification degradation modification graft modification

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