Antiviral activity of C-alkylated purine nucleosides obtained by cross-coupling with tetraalkyltin reagents

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ID: 113107
1993
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Abstract
2-, 6-, And 8-alkylated (methyl, ethyl, and vinyl) adenosine analogues were synthesized by a palladium-catalyzed cross-coupling of a tetraalkyltin with the halogenated purine nucleosides. The synthesis of the 8-substituted analogues was accomplished using a transient protection procedure. The 6-alky …
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Authors Van Aerschot AA;Mamos P;Weyns NJ;Ikeda S;De Clercq E;Herdewijn PA;;
Journal Journal of medicinal chemistry
Year 1993
DOI
DOI not found
URL
http://www.ncbi.nlm.nih.gov/pubmed/8411010
Keywords
National Center for Biotechnology Information NCBI NLM MEDLINE humans pubmed abstract nih national institutes of health national library of medicine research support non-u.s. gov't cell line herpesvirus 1 pmid:8411010 doi:10.1021/jm00072a013 a a van aerschot p mamos p a herdewijn adenosine / analogs & derivatives* adenosine / chemical synthesis adenosine / pharmacology antiviral agents / chemical synthesis* antiviral agents / pharmacology hiv-1 / drug effects hiv-2 / drug effects human / drug effects indicators and reagents organotin compounds* respiratory syncytial viruses / drug effects vaccinia virus / drug effects

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