pyrazolopyrimidines

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1
Pyrazolopyrimide library screening in glioma cells discovers highly potent antiproliferative leads that target the PI3K/mTOR pathway.
Valero, Teresa;Baillache, Daniel J;Fraser, Craig;Myers, Samuel H;Unciti-Broceta, Asier;
2020 bioorganic & medicinal chemistry DOI: S0968-0896(19)31128-... 308 views
2
A pyrazolopyrimidine based fluorescent probe for the detection of Cu and Ni and its application in living cells.
Gu, Yun-Qiong;Shen, Wen-Ying;Zhou, Yan;Chen, Shan-Feng;Mi, Yan;Long, Bing-Fan;Young, David J;Hu, Fei...
2019 spectrochimica acta part a, molecular and biomolec... DOI: S1386-1425(18)30957-... 238 views
3
Acid Derivatives of Pyrazolo[1,5-a]pyrimidine as Aldose Reductase Differential Inhibitors.
Balestri, Francesco;Quattrini, Luca;Coviello, Vito;Sartini, Stefania;Da Settimo, Federico;Cappiello,...
2018 cell chemical biology DOI: S2451-9456(18)30260-... 220 views
4
Design, Synthesis and Antitumor Evaluation of Novel Pyrazolopyrimidines and Pyrazoloquinazolines.
El-Naggar, Mohamed;Hassan, Ashraf S;Awad, Hanem M;Mady, Mohamed F;
2018 molecules DOI: E1249 640 views
5
5-Aminopyrazole as precursor in design and synthesis of fused pyrazoloazines.
Aggarwal, Ranjana;Kumar, Suresh;
2018 Beilstein journal of organic chemistry DOI: 10.3762/bjoc.14.15 204 views
6
Structure-Guided Development of Covalent and Mutant-Selective Pyrazolopyrimidines to Target T790M Drug Resistance in Epidermal Growth Factor Receptor.
Engel, Julian;Smith, Steven;Lategahn, Jonas;Tumbrink, Hannah L;Goebel, Lisa;Becker, Christian;Hennes...
2017 Journal of medicinal chemistry DOI: 10.1021/acs.jmedchem... 263 views
7
Novel pyrazolopyrimidines: Synthesis, in vitro cytotoxic activity and mechanistic investigation.
Hassan, Ghaneya S;Abdel Rahman, Doaa E;Nissan, Yassin M;Abdelmajeed, Esraa A;Abdelghany, Tamer M;
2017 European journal of medicinal chemistry DOI: S0223-5234(17)30525-... 372 views

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anticancer drugs kinase inhibitors ligand-based drug discovery phenotypic screening cu(2+) sensing, ni(2+) sensing fluorescent sensor aldose reductase aldose reductase differential inhibitors aldose reductase inhibitors synthesis antitumor activity cell cycle analysis pyrazoloquinazolines 5-aminopyrazoles fused pyrazole derivatives pyrazolopyridines pyrazolotriazines Cytotoxicity apoptosis cdk2 inhibitor