A pyrazolopyrimidine based fluorescent probe for the detection of Cu and Ni and its application in living cells.

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ID: 77184
2019
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Abstract
A fluorescent sensor L based on a pyrazolopyrimidine core simultaneously detects Cu and Ni ions by photoluminescence quenching, even in the presence of other metal cations. Sensor L possesses high association constants of 5.24 × 10 M and 2.85 × 10 M and low detection limits of 0.043 μM and 0.038 μM for Cu and Ni, respectively. The binding stoichiometry ratios of L to Cu or Ni is 1:1 as determined by Benesi-Hildebrand and Job's plots, and by crystal structures. DFT calculations on L-Cu indicated reduced electron donation from the coordinated pyrazolopyridine to the fused pyrimidine and pendant phenyl group which, together with a smaller HOMO-LUMO orbital gap could favour non-radiative decay and explain the observed fluorescence quenching. Sensor L possessed low cytotoxicity and good imaging characteristics for Cu and Ni in living cells, suggesting potential applications for detecting Cu and Niin vivo.
Reference Key
gu2019aspectrochimica Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gu, Yun-Qiong;Shen, Wen-Ying;Zhou, Yan;Chen, Shan-Feng;Mi, Yan;Long, Bing-Fan;Young, David J;Hu, Fei-Long;
Journal spectrochimica acta part a, molecular and biomolecular spectroscopy
Year 2019
DOI
S1386-1425(18)30957-0
URL
Keywords
pyrazolopyrimidines cu(2+) sensing, ni(2+) sensing fluorescent sensor

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