Potential Role of HLA Class I Antigens in the Glycolytic Metabolism and Motility of Melanoma Cells.

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ID: 45409
2019
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Abstract
Besides playing a crucial role in immune surveillance, human leukocyte antigens (HLA) possess numerous non-immune functions involved in cell communication. In the present study, screening of a panel of HLA class I- and HLA class II-specific monoclonal antibodies (mAbs) for their effects on the metabolism of human melanoma cells showed for the first time that the HLA-B,C-specific mAb B1.23.2 reduced the expression level of key glycolytic enzymes, but did not affect that of mitochondrial respiration effectors. As a result, the metabolism of melanoma cells shifted from a Warburg metabolism to a more oxidative phosphorylation. In addition, the HLA-B,C-specific mAb B1.23.2 downregulated the expression of glutamine transporter and glutaminase enzyme participating in the reduction of tricarboxylic acid cycle. The HLA-B,C-specific mAb B1.23.2-mediated reduction in energy production was associated with a reduction of melanoma cell motility. On the whole, the described results suggest that HLA class I antigens, and in particular the gene products of HLA-B and C loci play a role in the motility of melanoma cells by regulating their metabolism.
Reference Key
peppicelli2019potentialcancers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Peppicelli, Silvia;Ruzzolini, Jessica;Andreucci, Elena;Bianchini, Francesca;Kontos, Filippos;Yamada, Teppei;Ferrone, Soldano;Calorini, Lido;
Journal Cancers
Year 2019
DOI
E1249
URL
Keywords
hla class i glycolytic metabolism melanoma cells motility synthesis antitumor activity pyrazolopyrimidines cell cycle analysis pyrazoloquinazolines

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