carbon nanotubes: solution for the therapeutic delivery of sirna?

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ID: 245015
2012
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Abstract
Carbon nanotubes have many unique physical and chemical properties that are being widely explored for potential applications in biomedicine especially as transporters of drugs, proteins, DNA and RNA into cells. Specifically, single-walled carbon nanotubes (SWCNT) have been shown to deliver siRNA to tumors in vivo. The low toxicity, the excellent membrane penetration ability, the protection afforded against blood breakdown of the siRNA payload and the good biological activity seen in vivo suggests that SWCNT may become universal transfection vehicles for siRNA and other RNAs for therapeutic applications. This paper will introduce a short review of a number of therapeutic applications for carbon nanotubes and provide recent data suggesting SWCNT are an excellent option for the delivery of siRNA clinically.
Reference Key
gliko2012materialscarbon Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Olga Gliko;R. Bruce Weisman;D. Lynn Kirkpatrick;Geoffrey Bartholomeusz;Anton Naumov;Michelle Weiss
Journal Nature Materials
Year 2012
DOI
10.3390/ma5020278
URL
http://www.mdpi.com/1996-1944/5/2/278/
Keywords
electronics civil engineering (general)microscopydescriptive and experimental mechanics nuclear engineeringengineering (general) therapeutic deliverytechnologyelectrical engineering short interfering rna

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