biocompatibility and inflammatory potential of titanium alloys cultivated with human osteoblasts, fibroblasts and macrophages

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2017
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Abstract
The biomaterials used to maintain or replace functions in the human body consist mainly of metals, ceramics or polymers. In orthopedic surgery, metallic materials, especially titanium and its alloys, are the most common, due to their excellent mechanical properties, corrosion resistance, and biocompatibility. Aside from the established Ti6Al4V alloy, shape memory materials such as nickel-titanium (NiTi) have risen in importance, but are also discussed because of the adverse effects of nickel ions. These might be reduced by specific surface modifications. In the present in vitro study, the osteoblastic cell line MG-63 as well as primary human osteoblasts, fibroblasts, and macrophages were cultured on titanium alloys (forged Ti6Al4V, additive manufactured Ti6Al4V, NiTi, and Diamond-Like-Carbon (DLC)-coated NiTi) to verify their specific biocompatibility and inflammatory potential. Additive manufactured Ti6Al4V and NiTi revealed the highest levels of metabolic cell activity. DLC-coated NiTi appeared as a suitable surface for cell growth, showing the highest collagen production. None of the implant materials caused a strong inflammatory response. In general, no distinct cell-specific response could be observed for the materials and surface coating used. In summary, all tested titanium alloys seem to be biologically appropriate for application in orthopedic surgery.
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markhoff2017materialsbiocompatibility Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jana Markhoff;Martin Krogull;Christian Schulze;Christian Rotsch;Sandra Hunger;Rainer Bader
Journal Nature Materials
Year 2017
DOI
10.3390/ma10010052
URL
http://www.mdpi.com/1996-1944/10/1/52
Keywords
cell viability electronics civil engineering (general)microscopydescriptive and experimental mechanics nuclear engineeringengineering (general)

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