polymer-ceramic composite scaffolds: the effect of hydroxyapatite and β-tri-calcium phosphate

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ID: 221245
2018
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Abstract
The design of bioactive scaffolds with improved mechanical and biological properties is an important topic of research. This paper investigates the use of polymer-ceramic composite scaffolds for bone tissue engineering. Different ceramic materials (hydroxyapatite (HA) and β-tri-calcium phosphate (TCP)) were mixed with poly-ε-caprolactone (PCL). Scaffolds with different material compositions were produced using an extrusion-based additive manufacturing system. The produced scaffolds were physically and chemically assessed, considering mechanical, wettability, scanning electron microscopy and thermal gravimetric tests. Cell viability, attachment and proliferation tests were performed using human adipose derived stem cells (hADSCs). Results show that scaffolds containing HA present better biological properties and TCP scaffolds present improved mechanical properties. It was also possible to observe that the addition of ceramic particles had no effect on the wettability of the scaffolds.
Reference Key
huang2018materialspolymer-ceramic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Boyang Huang;Guilherme Caetano;Cian Vyas;Jonny James Blaker;Carl Diver;Paulo Bártolo
Journal Nature Materials
Year 2018
DOI
10.3390/ma11010129
URL
http://www.mdpi.com/1996-1944/11/1/129
Keywords
3d printing hydroxyapatite scaffold electronics civil engineering (general)microscopydescriptive and experimental mechanics nuclear engineeringengineering (general)

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