polydopamine-supported lipid bilayers

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ID: 194794
2012
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Abstract
We report the formation of lipid membranes supported by a soft polymeric cushion of polydopamine. First, 20 nm thick polydopamine films were formed on mica substrates. Atomic force microscopy imaging indicated that these films were also soft with a surface roughness of 2 nm under hydrated conditions. A zwitterionic phospholipid bilayer was then deposited on the polydopamine cushion by fusion of dimyristoylphosphatidylcholine (DMPC) and dioleoylphosphatidylcholine (DOPC) vesicles. Polydopamine films preserved the lateral mobility of the phospholipids as shown by fluorescence microscopy recovery after photobleaching (FRAP) experiments. Diffusion coefficients of ~5.9 and 7.2 µm2 s−1 were respectively determined for DMPC and DOPC at room temperature, values which are characteristic of lipids in a free standing bilayer system.
Reference Key
nirasay2012materialspolydopamine-supported Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Souryvanh Nirasay;Antonella Badia;Grégoire Leclair;Jerome P. Claverie;Isabelle Marcotte
Journal Nature Materials
Year 2012
DOI
10.3390/ma5122621
URL
http://www.mdpi.com/1996-1944/5/12/2621
Keywords
polydopamine phospholipid bilayer electronics civil engineering (general)microscopydescriptive and experimental mechanics nuclear engineeringengineering (general)

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