pbpk

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1
Comparing translational population-PBPK modelling of brain microdialysis with bottom-up prediction of brain-to-plasma distribution in rat and human.
Ball, Kathryn;Bouzom, François;Scherrmann, Jean-Michel;Walther, Bernard;Declèves, Xavier;
2014 biopharmaceutics & drug disposition DOI: 10.1002/bdd.1908 276 views
2
ArchDB 2014: structural classification of loops in proteins.
Bonet, Jaume;Planas-Iglesias, Joan;Garcia-Garcia, Javier;Marín-López, Manuel A;Fernandez-Fuentes, Na...
2014 Nucleic Acids Research DOI: 10.1093/nar/gkt1189 255 views
3
Exposure to second-hand smoke at home and its associated factors: findings from the Global Adult Tobacco Use survey in Vietnam, 2010.
Minh, Hoang Van;Giang, Kim Bao;Xuan, Le Thi Thanh;Nga, Pham Thi Quynh;Hai, Phan Thi;Minh, Nguyen Tha...
2012 cancer causes & control : ccc DOI: 10.1007/s10552-012-9... 275 views
4
In vivo monitoring of bone-implant bond strength by microCT and finite element modelling.
Stadelmann, Vincent A;Conway, Carl M;Boyd, Steven K;
2013 Computer methods in biomechanics and biomedical en... DOI: 10.1080/10255842.201... 310 views
5
Frailty modelling for survival data from multi-centre clinical trials.
Ha, Il Do;Sylvester, Richard;Legrand, Catherine;Mackenzie, Gilbert;
2011 Statistics in Medicine DOI: 10.1002/sim.4250 254 views
6
Open Systems Pharmacology community - an open access, open source, open science approach to modeling and simulation in pharmaceutical sciences.
Lippert, Jörg;Burghaus, Rolf;Edginton, Andrea;Frechen, Sebastian;Karlsson, Mats;Kovar, Andreas;Lehr,...
2019 cpt: pharmacometrics & systems pharmacology DOI: 10.1002/psp4.12473 335 views
7
Justification of Drug Product Dissolution Rate and Drug Substance Particle Size Specifications Based on Absorption PBPK Modeling for Lesinurad Immediate Release Tablets.
Pepin, Xavier J H;Flanagan, Talia R;Holt, David J;Eidelman, Anna;Treacy, Don;Rowlings, Colin E;
2016 molecular pharmaceutics DOI: 10.1021/acs.molpharm... 303 views
8
A systematic evaluation of the safety and toxicity of fingolimod for its potential use in the treatment of acute myeloid leukaemia.
Enjeti, Anoop K;D'Crus, Angel;Melville, Kathleen;Verrills, Nicole M;Rowlings, Philip;
2016 anti-cancer drugs DOI: 10.1097/CAD.00000000... 290 views
9
A multilevel object-oriented modelling methodology for physiologically-based pharmacokinetics (PBPK): Evaluation with a semi-mechanistic pharmacokinetic model.
Reig-Lopez, J;Merino-Sanjuan, M;Mangas-Sanjuan, V;Prado-Velasco, M;
2020 computer methods and programs in biomedicine DOI: S0169-2607(19)31803-... 207 views
10
Mechanistic multi-scale pharmacokinetic model for the anticancer drug gemcitabine in pancreatic cancer.
Garcia-Cremades, Maria;Melillo, Nicola;Troconiz, Iñaki F;Magni, Paolo;
2020 clinical and translational science DOI: 10.1111/cts.12747 307 views
11
Bio-informational futures: The convergence of artificial intelligence and synthetic biology.
A Dixon, Thom;C Curach, Natalie;Pretorius, Isak S;
2020 EMBO reports DOI: 10.15252/embr.202050... 285 views
12
Physiologically-based pharmacokinetic models for children: Starting to reach maturation?
Verscheijden, Laurens F M;Koenderink, Jan B;Johnson, Trevor N;de Wildt, Saskia N;Russel, Frans G M;
2020 pharmacology & therapeutics DOI: S0163-7258(20)30069-... 242 views
13
a workflow for global sensitivity analysis of pbpk models
;Kevin eMcNally;Richard eCotton;George D Loizou
2011 chemical research in chinese universities DOI: 10.3389/fphar.2011.0... 187 views
14
pbpk modeling and simulation in drug research and development
;Xiaomei Zhuang;Chuang Lu
2016 energy policy DOI: 10.1016/j.apsb.2016.... 190 views

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modelling microdialysis cns translational Simulation PD open source modeling open science pharmacology systems pharmacology open access open innovation pk pharmaceutical sciences control strategy dissolution biowaiver specifications metabolites