Dissemination and conservation of cadmium and arsenic resistance determinants in Listeria and other Gram-positive bacteria.

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ID: 86845
2020
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Abstract
Metal homeostasis in bacteria is a complex and delicate balance. While some metals such as iron and copper are essential for cellular functions, others such as cadmium and arsenic are inherently cytotoxic. While bacteria regularly encounter essential metals, exposure to high levels of toxic metals such as cadmium and arsenic is only experienced in a handful of special habitats. Nonetheless, Listeria and other Gram-positive bacteria have evolved an impressively diverse array of genetic tools for acquiring enhanced tolerance to such metals. Here we summarize this fascinating collection of resistance determinants in Listeria, with special focus on resistance to cadmium and arsenic, as well as to biocides and antibiotics. We also provide a comparative description of such resistance determinants and adaptations in other Gram-positive bacteria. The complex co-selection of heavy metal resistance and other types of resistance seems to be universal across the Gram-positive bacteria while the type of co-selected traits reflects the lifestyle of the specific microbe. The roles of heavy metal resistance genes in environmental adaptation and virulence appear to vary by genus, highlighting the need for further functional studies to explain the mystery behind the array of heavy metal resistance determinants dispersed and maintained among Gram-positive bacteria.
Reference Key
parsons2020disseminationmolecular Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Parsons, Cameron;Lee, Sangmi;Kathariou, Sophia;
Journal molecular microbiology
Year 2020
DOI
10.1111/mmi.14470
URL
Keywords
resistance antibiotic lactic acid bacteria arsenic cadmium co-selection biocide enterococcus listeria staphylococcus streptococcus gram-positive bacteria

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