Motor repertoire and gray matter plasticity: Is there a link?

There is a considerable amount of evidence sustaining that aerobic exercise causes positive modifications in gray matter density (GMD), especially in the hippocampus and anterior cingulate cortex. However, recent experimental researches with motor learning paradigms are consistently showing that increasing cardiorespiratory capacity is not the only mechanism able to promote positive outcomes in GMD with exercise. In the present study, we present a theoretical suggestion that expanding one's motor repertoire is another primary mechanism related to the increases in GMD. Motor repertoire can be understood as the number of movement possibilities and motor skills that can be performed by a person. Supporting our suggestion, professional athletes present higher GMD than controls, and experimental protocols repeatedly observes positive changes in GMD following motor learning. The relationship between physical inactivity, amputation, and lower GMD values also gives further support for the hypothesis. Follow-up studies monitoring GMD before and after training programs that stimulate new motor skill learning are essential to confirm this proposition. The brain regions related to sensory processing of the motor tasks and the cortical areas related to motor control (e.g., primary motor cortex, supplementary motor area) are probably the ones most affected by plastic changes. If the hypothesis turns out to be reliable, dancing, gymnastics, and other movement-rich activities are thoroughly encouraged for this purpose. Therefore, this approach might be used to attenuate GMD loss related to aging or another condition, such as Parkinson's and Alzheimer's.