the effect of percutaneous coronary revascularization on plasma n-terminal pro-b-type natriuretic peptide levels in stable coronary artery disease

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ID: 259349
2018
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Abstract
Background: This study was conducted to assess the effect of percutaneous coronary revascularization (PCR) on plasma NT-proBNP concentration in patients with chronic stable angina (CSA). Methods: This prospective open label interventional study included 22 patients with moderate to severe CSA, normal left ventricular (LV) systolic functions and critical (>90%) proximal stenosis in one of the three major epicardial coronary arteries. After stabilization of medications for 8 weeks, resting supine plasma NT-proBNP levels were measured and patients underwent PCR of the involved vessels. Eight weeks later, with medications unaltered; plasma NT-proBNP levels were repeated and compared with the baseline levels. LV systolic and diastolic functions were assessed before and after PCR. Results: The mean age of the patients was 61.27 ± 8.87 years. Out of 22 patients, 20 were male and 2 were female. PCR was performed on left anterior descending coronary artery (LAD) in 12 patients and in a non-LAD vessel in 10 patients. After 8 weeks of successful PCR, there was a significant overall reduction in mean plasma NT-proBNP levels (from 244.36 ± 218.99 to 168.68 ± 161.61 pg/mL, p = 0.016). The patients who underwent PCR of LAD demonstrated significantly reduced NT-pro-BNP levels after PCR (p = 0.009). In the non-LAD group, NT-proBNP levels also decreased, albeit insignificantly (p = 0.432). Reduction in NT-proBNP was independent of change in LV systolic functions. Conclusion: Successful PCR, by relieving myocardial ischemia, significantly reduced plasma NT-proBNP levels in majority of the patients with chronic stable angina secondary to critical epicardial coronary artery stenosis. Keywords: Coronary artery disease, Chronic stable angina, NT-ProBNP, Percutaneous coronary revascularization
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gupta2018indianthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Amit Gupta, Jahangir Rashid Beig, Nisar A. Tramboo, Dil Afroze, Imran Hafeez, Hilal A. Rather
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Journal renewable energy
Year 2018
DOI
DOI not found
URL
http://www.sciencedirect.com/science/article/pii/S0019483216309750
Keywords
Children prognosis lipids albumin burns bronchial asthma allergy surgerydiseases of the circulatory (cardiovascular) system

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