role of the aryl hydrocarbon receptor in colon neoplasia

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ID: 224824
2015
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Abstract
For both men and women, colorectal cancer (CRC) is the second leading cause of cancer death in the United States, primarily as a consequence of limited therapies for metastatic disease. The aryl hydrocarbon receptor (AhR) is a ligand-dependent transcription factor with diverse functions in detoxification of xenobiotics, inflammatory responses, and tissue homeostasis. Emerging evidence indicates that AhR also plays an important role in regulating intestinal cell proliferation and tumorigenesis. Here, we review both the pro- and anti-carcinogenic properties of AhR signaling and its potential role as a therapeutic target in CRC.
Reference Key
xie2015cancersrole Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Guofeng Xie;Jean-Pierre Raufman
Journal The Journal of investigative dermatology
Year 2015
DOI
10.3390/cancers7030847
URL
http://www.mdpi.com/2072-6694/7/3/0847
Keywords
colorectal cancer aryl hydrocarbon receptor tcdd Oncology including cancer and carcinogens tumors

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