ldl biochemical modifications: a link between atherosclerosis and aging

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ID: 223338
2015
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Abstract
Atherosclerosis is an aging disease in which increasing age is a risk factor. Modified low-density lipoprotein (LDL) is a well-known risk marker for cardiovascular disease. High-plasma LDL concentrations and modifications, such as oxidation, glycosylation, carbamylation and glycoxidation, have been shown to be proatherogenic experimentally in vitro and in vivo. Atherosclerosis results from alterations to LDL in the arterial wall by reactive oxygen species (ROS). Evidence suggests that common risk factors for atherosclerosis raise the likelihood that free ROS are produced from endothelial cells and other cells. Furthermore, oxidative stress is an important factor in the induction of endothelial senescence. Thus, endothelial damage and cellular senescence are well-established markers for atherosclerosis. This review examines LDL modifications and discusses the mechanisms of the pathology of atherosclerosis due to aging, including endothelial damage and oxidative stress, and the link between aging and atherosclerosis.
Reference Key
alique2015foodldl Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Matilde Alique;Carlos Luna;Julia Carracedo;Rafael Ramírez
Journal scandinavian journal of pain
Year 2015
DOI
10.3402/fnr.v59.29240
URL
http://www.foodandnutritionresearch.net/index.php/fnr/article/view/29240/43622
Keywords
aging atherosclerosis foods and food supply

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