anti-inflammatory, analgesic, and immunostimulatory effects of luehea divaricata mart. & zucc. (malvaceae) bark
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ID: 216912
2014
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Luehea divaricata (Malvaceae) is a plant widely used for treatment of various inflammatory and infectious conditions; however few reports discuss its biological properties. The aim of this study was to evaluate the anti-inflammatory and analgesic effects as well as the macrophage activity in mice treated with the hydroalcoholic crude extract of L. divaricata(CLD). Thin layer chromatography revealed presence of epicathequin, stigmasterol, lupeol and α,β-amyrin in the extract. To evaluate the anti-inflammatory and analgesic activities, animals were subjected to paw edema induced by carrageenan test, writhing, formalin and capsaicin tests. Immunomodulatory activity was evaluated by adhesion and phagocytic capacity, lysosomal volume, and reactive oxygen species (ROS) production by peritoneal macrophages, after daily treatment with CLD for 15 days. CLD promoted reduction in paw edema (36.8% and 50.2%; p<0.05 at doses of 100 and 300 mg/kg, respectively), inhibited writhing behavior at the higher dose (64.4%, p<0.05), reduced formalin reactivity (81.2% and 91.6% at doses of 100 and 300 mg/kg, respectively, p<0.05), and reduced capsaicin reactivity by 63.9% (300 mg/kg). CLD (200 mg• kg-1• day-1) increased phagocytosis capacity of macrophages (~3 fold, p<0.05), neutral red uptake (~50%, p<0.001), and ROS production (~90%, p<0.001). These data suggest that CLD possesses anti-inflammatory, analgesic and immunostimulatory properties.
| Kunci Referensi |
rosa2014braziliananti-inflammatory,
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|---|---|
| Penulis | ;Roseane Leandra da Rosa;Geisson Marcos Nardi;Adriana Graziele de Farias Januário;Renata Boçois;Katiane Paula Bagatini;Sandro José Ribeiro Bonatto;Andrea de Oliveira Pinto;João Ronaldo Notargiacomo Ferreira;Luisa Nathália Bolda Mariano;Rivaldo Niero;Fabíola Iagher |
| Jurnal | electronic engineering times |
| Tahun | 2014 |
| DOI |
10.1590/S1984-82502014000300020
|
| URL | |
| Kata Kunci |
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