flaxseed ingestion alters ratio of enterolactone enantiomers in human serum

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ID: 192685
2010
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Abstract
Enterolactone (EL) is an enterolignan found in human subjects. In this pilot study, the enantiomeric ratios of serum EL were determined in serum from healthy adults during consumption of habitual diet, and after an 8-day supplementation with flaxseed (25 g/day). (−)EL dominated in all serum samples collected during habitual diet consumption. However, the ratio of (−)EL and (+)EL enantiomers differed markedly between individuals. Flaxseed ingestion increased significantly the proportion of (+)EL in all subjects. Moreover, a small but significant increase in serum (−)EL concentration was measured. After flaxseed ingestion, (−)EL concentrations correlated with those of (+)EL suggesting that the stereochemistry of the parent plant lignan in flaxseed is not a major determinant of EL formation in human subjects. Comparison of EL concentrations obtained with the validated chromatographic methods (HPLC-MS/MS, HPLC-CEAD, and GC-MS) and the time-resolved fluoroimmunoassay (TR-FIA) revealed that the immunoassay method underestimates human serum EL concentrations after the flaxseed ingestion.
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saarinen2010journalflaxseed Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Niina M. Saarinen;Annika I. Smeds;José L. Peñalvo;Tarja Nurmi;Herman Adlercreutz;Sari Mäkelä
Journal PLoS pathogens
Year 2010
DOI
10.1155/2010/403076
URL
http://dx.doi.org/10.1155/2010/403076
Keywords
nutritional diseases deficiency diseases

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