d-α-tocopherol nanoemulsions: size properties, rheological behavior, surface tension, osmolarity and cytotoxicity
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ID: 189122
2017
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Abstract
The aim of this study was the assessment of the physicochemical stability of d-α-tocopherol formulated in medium chain triglyceride nanoemulsions, stabilized with Tween®80 and Lipoid®S75 as surfactant and co-surfactant, respectively. d-α-tocopherol was selected as active ingredient because of its well-recognized interesting anti-oxidant properties (such as radical scavenger) for food and pharmaceutical industries. A series of nanoemulsions of mean droplet size below 90 nm (polydispersity index < 0.15) have been produced by high-pressure homogenization, and their surface electrical charge (zeta potential), pH, surface tension, osmolarity, and rheological behavior, were characterized as a function of the d-α-tocopherol loading. In vitro studies in Caco-2 cell lines confirmed the safety profile of the developed nanoemulsions with percentage of cell viability above 90% for all formulations.
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| Reference Key |
teixeira2017saudid--tocopherol
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|---|---|
| Authors | ;M.C. Teixeira;P. Severino;T. Andreani;P. Boonme;A. Santini;A.M. Silva;E.B. Souto |
| Journal | International journal for quality in health care : journal of the International Society for Quality in Health Care |
| Year | 2017 |
| DOI |
10.1016/j.jsps.2016.06.004
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