multi-toxic endpoints of the foodborne mycotoxins in nematode caenorhabditis elegans

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ID: 179380
2015
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Abstract
Aflatoxins B1 (AFB1), deoxynivalenol (DON), fumonisin B1 (FB1), T-2 toxin (T-2), and zearalenone (ZEA) are the major foodborne mycotoxins of public health concerns. In the present study, the multiple toxic endpoints of these naturally-occurring mycotoxins were evaluated in Caenorhabditis elegans model for their lethality, toxic effects on growth and reproduction, as well as influence on lifespan. We found that the lethality endpoint was more sensitive for T-2 toxicity with the EC50 at 1.38 mg/L, the growth endpoint was relatively sensitive for AFB1 toxic effects, and the reproduction endpoint was more sensitive for toxicities of AFB1, FB1, and ZEA. Moreover, the lifespan endpoint was sensitive to toxic effects of all five tested mycotoxins. Data obtained from this study may serve as an important contribution to knowledge on assessment of mycotoxin toxic effects, especially for assessing developmental and reproductive toxic effects, using the C. elegans model.
Reference Key
yang2015toxinsmulti-toxic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Zhendong Yang;Kathy S. Xue;Xiulan Sun;Lili Tang;Jia-Sheng Wang
Journal matec web of conferences
Year 2015
DOI
10.3390/toxins7124876
URL
http://www.mdpi.com/2072-6651/7/12/4876
Keywords
mycotoxins caenorhabditis elegans aflatoxin b1 deoxynivalenol t-2 toxin fumonisin b1

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