immune system regulation in the induction of broadly neutralizing hiv-1 antibodies
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ID: 173526
2013
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Abstract
In this brief review, we discuss immune tolerance as a factor that determines the magnitude and quality of serum antibody responses to HIV-1 infection and vaccination in the context of recent work. We propose that many conserved, neutralizing epitopes of HIV-1 are weakly immunogenic because they mimic host antigens. In consequence, B cells that strongly bind these determinants are removed by the physiological process of immune tolerance. This structural mimicry may represent a significant impediment to designing protective HIV-1 vaccines, but we note that several vaccine strategies may be able to mitigate this evolutionary adaptation of HIV and other microbial pathogens.
| Reference Key |
kelsoe2013vaccinesimmune
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|---|---|
| Authors | ;Garnett Kelsoe;Laurent Verkoczy;Barton F. Haynes |
| Journal | Tuberkuloz ve toraks |
| Year | 2013 |
| DOI |
10.3390/vaccines2010001
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| URL | |
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