synthesis of biocompatible hydroxyapatite using chitosan oligosaccharide as a template
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2015
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Abstract
In this study, a novel biocompatible hydroxyapatite (HA) was synthesized by using chitosan oligosaccharide (COS) as a template. These HA samples were studied by Fourier transform infrared (FTIR) spectroscopy, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and transmission electron microscopy (TEM). The biocompatibility of HA samples was evaluated via cell viability, cell morphology and alkaline phosphatase staining of MG-63 cell lines. The results show that HA synthesized in the presence of COS was favorable to proliferation and osteogenic differentiation of MG-63 cells. These hydroxyapatites are potentially attractive biomaterials for bone tissue engineering applications.
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| Reference Key |
wang2015materialssynthesis
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| Authors | ;Jinyu Wang;Guanxiong Liu;Jinshuai Chen;Bo Zhao;Peizhi Zhu |
| Journal | Nature Materials |
| Year | 2015 |
| DOI |
10.3390/ma8125440
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| URL | |
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