the natural history of ige-mediated food allergy: can skin prick tests and serum-specific ige predict the resolution of food allergy?

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ID: 151874
2013
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Abstract
IgE-mediated food allergy is a transient condition for some children, however there are few indices to predict when and in whom food allergy will resolve. Skin prick test (SPT) and serum-specific IgE levels (sIgE) are usually monitored in the management of food allergy and are used to predict the development of tolerance or persistence of food allergy. The aim of this article is to review the published literature that investigated the predictive value of SPT and sIgE in development of tolerance in children with a previous diagnosis of peanut, egg and milk allergy. A systematic search identified twenty-six studies, of which most reported SPT or sIgE thresholds which predicted persistent or resolved allergy. However, results were inconsistent between studies. Previous research was hampered by several limitations including the absence of gold standard test to diagnose food allergy or tolerance, biased samples in retrospective audits and lack of systematic protocols for triggering re-challenges. There is a need for population-based, prospective studies that use the gold standard oral food challenge (OFC) to diagnose food allergy at baseline and follow-up to develop SPT and sIgE thresholds that predict the course of  food allergy.
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koplin2013internationalthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors ;Jennifer J. Koplin;Rachel L. Peters;Lyle C. Gurrin;Shyamali C. Dharmage;Katrina J. Allen
Journal archives of biochemistry and biophysics
Year 2013
DOI
10.3390/ijerph10105039
URL
http://www.mdpi.com/1660-4601/10/10/5039
Keywords
food allergy tolerance natural history hen’s egg peanut

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