the architecture of the rag gtpase signaling network

النقرات: 116
المعرّف: 139940
2017
PDF مجاني
مقاييس جودة وأداء المقال
الجودة الإجمالية
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
تقييم الجودة بالذكاء الاصطناعي
لم يتم التحليل
Readership in this journal
Steady

Ranked #54 of 60 articles by views in international journal of middle east studies

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
الملخص
The evolutionarily conserved target of rapamycin complex 1 (TORC1) couples an array of intra- and extracellular stimuli to cell growth, proliferation and metabolism, and its deregulation is associated with various human pathologies such as immunodeficiency, epilepsy, and cancer. Among the diverse stimuli impinging on TORC1, amino acids represent essential input signals, but how they control TORC1 has long remained a mystery. The recent discovery of the Rag GTPases, which assemble as heterodimeric complexes on vacuolar/lysosomal membranes, as central elements of an amino acid signaling network upstream of TORC1 in yeast, flies, and mammalian cells represented a breakthrough in this field. Here, we review the architecture of the Rag GTPase signaling network with a special focus on structural aspects of the Rag GTPases and their regulators in yeast and highlight both the evolutionary conservation and divergence of the mechanisms that control Rag GTPases.
المفتاح المرجعي
nicastro2017biomoleculesthe استخدم هذا المفتاح للاستشهاد التلقائي في المخطوطة أثناء استخدام مدير المخطوطات أو مدير الأطروحات من SciMatic
المؤلفون ;Raffaele Nicastro;Alessandro Sardu;Nicolas Panchaud;Claudio De Virgilio
مجلة international journal of middle east studies
السنة 2017
DOI
10.3390/biom7030048
URL
http://www.mdpi.com/2218-273X/7/3/48
الكلمات المفتاحية
budding yeast lst4–lst7microbiology

الاستشهادات

لم يتم العثور على استشهادات. لإضافة استشهاد، تواصل مع المشرف على info@scimatic.org

التعليقات

لا توجد تعليقات بعد. كن أول من يعلق على هذا المقال.