Packaging and delivering enzymes by amorphous metal-organic frameworks.

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ID: 100255
2019
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Abstract
Enzymatic catalysis in living cells enables the in-situ detection of cellular metabolites in single cells, which could contribute to early diagnosis of diseases. In this study, enzyme is packaged in amorphous metal-organic frameworks (MOFs) via a one-pot co-precipitation process under ambient conditions, exhibiting 5-20 times higher apparent activity than when the enzyme is encapsulated in corresponding crystalline MOFs. Molecular simulation and cryo-electron tomography (Cryo-ET) combined with other techniques demonstrate that the mesopores generated in this disordered and fuzzy structure endow the packaged enzyme with high enzyme activity. The highly active glucose oxidase delivered by the amorphous MOF nanoparticles allows the noninvasive and facile measurement of glucose in single living cells, which can be used to distinguish between cancerous and normal cells.
Reference Key
wu2019packagingnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Wu, Xiaoling;Yue, Hua;Zhang, Yuanyu;Gao, Xiaoyong;Li, Xiaoyang;Wang, Licheng;Cao, Yufei;Hou, Miao;An, Haixia;Zhang, Lin;Li, Sai;Ma, Jingyuan;Lin, He;Fu, Yanan;Gu, Hongkai;Lou, Wenyong;Wei, Wei;Zare, Richard N;Ge, Jun;
Journal Nature communications
Year 2019
DOI
10.1038/s41467-019-13153-x
URL
Keywords
chemometrics icp-ms wine elemental data fuzzy clustering

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