allosteric modulation

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1
Thiazolidine-2,4-dione-based irreversible allosteric IKK-β kinase inhibitors: Optimization into in vivo active anti-inflammatory agents.
Elkamhawy, Ahmed;Kim, Nam Youn;Hassan, Ahmed H E;Park, Jung-Eun;Paik, Sora;Yang, Jeong-Eun;Oh, Kwang...
2019 European journal of medicinal chemistry DOI: S0223-5234(19)31107-... 227 views
2
Tacrine-xanomeline and tacrine-iperoxo hybrid ligands: Synthesis and biological evaluation at acetylcholinesterase and M muscarinic acetylcholine receptors.
Maspero, Marco;Volpato, Daniela;Cirillo, Davide;Yuan Chen, Natalia;Messerer, Regina;Sotriffer, Chris...
2020 Bioorganic chemistry DOI: S0045-2068(19)31569-... 220 views
3
1-(2',5'-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1-propanone (RGM079): A Positive Allosteric Modulator of α7 Nicotinic Receptors with Analgesic and Neuroprotective Activity.
Pérez de Vega, María Jesús;Fernandez-Mendivil, Cristina;de la Torre Martínez, Roberto;González-Rodrí...
2019 ACS chemical neuroscience DOI: 10.1021/acschemneuro... 252 views
4
Allosteric Modulation of Cannabinoid Receptor 1-Current Challenges and Future Opportunities.
Hryhorowicz, Szymon;Kaczmarek-Ryś, Marta;Andrzejewska, Angelika;Staszak, Klaudia;Hryhorowicz, Magdal...
2019 International journal of molecular sciences DOI: E5874 218 views

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anti-inflammatory ikk-β modulators nf-κb signaling pathway thiazolidine-2,4-diones bitopic ligands ellman’s assay inositol monophosphate iperoxo m(1) muscarinic acetylcholine receptor multitarget compounds phospholipase c tacrine xanomeline neuroprotection analgesia alzheimer’s disease diphenylpropanones α7 nicotinic receptors gpcr drug development