ethyl pyruvate protects against sepsis by regulating energy metabolism

Clics: 283
ID: 231458
2016
PDF Gratuit
Métriques de Qualité et de Performance de l'Article
Qualité Globale
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
Évaluation de la Qualité par IA
Non analysé
Readership in this journal
Steady

Ranked #20 of 91 articles by views in liver transplantation : official publication of the american association for the study of liver diseases and the international liver transplantation society

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Résumé
Hongjun Kang,1 Zhi Mao,1 Yan Zhao,1 Ting Yin,2 Qing Song,1 Liang Pan,1 Xin Hu,1 Jie Hu,1 Feihu Zhou1 1Department of Critical Care Medicine, Chinese PLA General Hospital, Beijing, 2Department of Critical Care Medicine, The Centre Hospital of BaoTou, BaoTou, People’s Republic of China Background: Ethyl pyruvate (EP) is a derivative of pyruvic acid that has been demonstrated to be a potential scavenger of reactive oxygen species as well as an anti-inflammatory agent. In this study, we investigated the protective effects of EP and its role in regulating the energy metabolism in the livers of cecal-ligation-and-puncture-induced septic mice. Methods: The animals were treated intraperitoneally with 0.2 mL of Ringer’s lactate solution or an equivalent volume of Ringer’s lactate solution containing EP immediately after cecal ligation and puncture. Each mouse in the Sham group was only subjected to a laparotomy. At 30-, 60-, 180-, and 360-minute time points, we measured the histopathological alterations of the intestines, and the plasma levels of interleukin (IL)-1β, IL-6, IL-10, and tumor necrosis factor-α, and the total antioxidative capacity, malondialdehyde content, and lactate and lactate/pyruvate levels in livers. Furthermore, we detected the levels of adenosine triphosphate, total adenylate, and energy charge in the livers. Results: Our results demonstrated that the administration of EP significantly improved the survival rate and reduced intestinal histological alterations. EP inhibited the plasma levels of IL-1β, IL-6, and tumor necrosis factor-α and increased the IL-10 level. EP significantly inhibited the elevation of the malondialdehyde, lactate, and lactate/pyruvate levels and enhanced the total antioxidative capacity levels in the liver tissues. The downregulation of the adenosine triphosphate, total adenylate, and energy charge levels in the liver tissues was reversed in the septic mice treated with EP. Conclusion: The results suggest that EP administration effectively modulates the energy metabolism, which may be an important component in treatment of sepsis. Keywords: sepsis, ethyl pyruvate, energy metabolism, inflammation, reactive oxygen species
Clé de Référence
h2016therapeuticsethyl Utilisez cette clé pour citer automatiquement dans le manuscrit lors de l'utilisation de SciMatic Manuscript Manager ou Thesis Manager
Auteurs ;Kang H;Mao Z;Zhao Y;Yin T;Song Q;Pan L;Hu X;Hu J;Zhou F
Revue liver transplantation : official publication of the american association for the study of liver diseases and the international liver transplantation society
Année 2016
DOI
DOI non trouvé
URL
https://www.dovepress.com/ethyl-pyruvate-protects-against-sepsis-by-regulating-energy-metabolism-peer-reviewed-article-TCRM
Mots-clés
Medicine (General) inflammation reactive oxygen species sepsis energy metabolism ethyl pyruvate

Citations

Aucune citation trouvée. Pour ajouter une citation, contactez l'administrateur à info@scimatic.org

Commentaires

Aucun commentaire pour le moment. Soyez le premier à commenter cet article.