Cyclin D1, Caspase 9 and P53 Expressions in T47D Cell Lines after Treatment of , (Lour.) Spreng. Leaves Ethanolic Extract Nanoparticles.

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ID: 99892
2019
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Abstract
The application of nanotechnology is aimed to enhance the capability of the chemical compounds of (Lour.) Spreng. leaves activity. The contact area of the particle surface becomes larger in nano size, which can increase the amount of the isolated active substance. The nanoparticles of this extract exhibited the most effective impact in decreasing the cell number of T47D by induction of apoptosis and arresting the cell cycle.To evaluate the expressions of cyclin D1, caspase-9 and p53 in T47D cell lines treated by Plectranthus amboinicus, (Lour.) Spreng. Leaves Ethanolic Extract Nanoparticles (PAEEN).The inhibition of cyclin D1 was done by flow cytometry assay. The expression of cyclin D1, caspase-9 and p53 were observed by immunocytochemistry assay., (Lour.) Spreng. Leaves Ethanolic Extract Nanoparticles (PAEEN) on concentration IC (89.2 µg/mL) inhibited the expression of cyclin D1 around 5.59%. Further, the immunocytochemistry assay indicated that there was an inhibition of cyclin D1, upregulation of caspase-9 and restoration of p53, indicated by their expression.The , (Lour.) Spreng. Leaves Ethanolic Extract Nanoparticles could be an effective anticancer by improving its downregulation on cyclinD1, upregulation caspase-9 and p53.
Reference Key
hasibuan2019cyclinopen Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Hasibuan, Poppy Anjelisa Zaitun;Sumaiyah, Sumaiyah;
Journal open access macedonian journal of medical sciences
Year 2019
DOI
10.3889/oamjms.2019.504
URL
Keywords
nanoparticle p53 cyclin d1 caspase-9 plectranthus ambonicus

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