Regioselective synthesis of 2-chloroquinoline based ethyl 4-(3- hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3- carboxylates and their in-silico evaluation against P. falciparum lactate dehydrogenase.

Clicks: 433
ID: 98893
2015
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Abstract
The reaction of various substituted 2, 4-dichloroquinolines with ethyl 4-(3-hydroxyphenyl)- 2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate was carried out in the presence of K2CO3 as a mild and efficient base at controlled temperature leading to novel 2-chloroquinoline based polyhydroquinoline with high regioselectivity. All the synthesized compounds were characterized using IR, NMR, Mass spectral data and then subjected to an in-silico analysis against P. falciparum lactate dehydrogenase.
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rajesh2015regioselectivemedicinal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Rajesh, Kancherla;Lavanya, Pandian;Iniyavan, Pethaperumal;Sarveswari, Sundaramoorthy;Ramaiah, Sudha;Anbarasu, Anand;Vijayakumar, Vijayaparthasarathi;
Journal medicinal chemistry (shariqah (united arab emirates))
Year 2015
DOI
DOI not found
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Keywords
green chemistry hantzsch esters biodegradable heterogeneous catalysis chitosan supported copper(ii) sulfate (cscs) multicomponent reactions (mcrs)

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