Regioselective synthesis of 2-chloroquinoline based ethyl 4-(3- hydroxyphenyl)-2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3- carboxylates and their in-silico evaluation against P. falciparum lactate dehydrogenase.
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2015
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Abstract
The reaction of various substituted 2, 4-dichloroquinolines with ethyl 4-(3-hydroxyphenyl)- 2,7,7-trimethyl-5-oxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate was carried out in the presence of K2CO3 as a mild and efficient base at controlled temperature leading to novel 2-chloroquinoline based polyhydroquinoline with high regioselectivity. All the synthesized compounds were characterized using IR, NMR, Mass spectral data and then subjected to an in-silico analysis against P. falciparum lactate dehydrogenase.
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rajesh2015regioselectivemedicinal
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| Authors | Rajesh, Kancherla;Lavanya, Pandian;Iniyavan, Pethaperumal;Sarveswari, Sundaramoorthy;Ramaiah, Sudha;Anbarasu, Anand;Vijayakumar, Vijayaparthasarathi; |
| Journal | medicinal chemistry (shariqah (united arab emirates)) |
| Year | 2015 |
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| URL | URL not found |
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