Modulation of Tight Junction Structure and Function by Kinases and Phosphatases Targeting Occludin

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ID: 98023
2012
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Abstract
Tight junctions (TJs) typically represent the most apical contacts in epithelial and endothelial cell layers where they play an essential role in the separation of extracellular or luminal spaces from underlying tissues in the body. Depending on the protein composition, TJs define the barrier characteristics and in addition maintain cell polarity. Two major families of integral membrane proteins form the typical TJ strand network, the tight junction-associated MARVEL protein (TAMP) family members occludin, tricellulin, and MarvelD3 as well as a specific set of claudins. Occludin was the first identified member of these tetraspanins and is now widely accepted as a regulator of TJ assembly and function. Therefore, occludin itself has to be tightly regulated. Phosphorylation of occludin appears to be of central importance in this context. Here we want to summarize current knowledge on the kinases and phosphatases directly modifying occludin, and their role in the regulation of TJ structure, function, and dynamics.
Reference Key
dorfel2012modulationjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dörfel, Max Johannes;Huber, Otmar;
Journal journal of biomedicine and biotechnology
Year 2012
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2012/807356
Keywords
chemistry Biology (General) Medicine Biotechnology Science cytology

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