Mice Selected for Acute Inflammation Present Altered Immune Response during Pristane-Induced Arthritis Progression

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ID: 97936
2018
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Abstract
Mouse lines selected for maximal (AIRmax) or minimal acute inflammatory reaction (AIRmin) were used to characterize the immune response and the influence of genetic background during pristane-induced arthritis (PIA). Susceptible AIRmax mice demonstrated exacerbated cellular profiles during PIA, with intense infiltration of lymphocytes, as well as monocytes/macrophages and neutrophils, producing higher levels of IL-1β, IFN-γ, TNF-α, IL-10, total IgG3, and chemokines. Resistant AIRmin mice controlled cell activation more efficiently than the AIRmax during arthritis progression. The weight alterations of the spleen and thymus in the course of PIA were observed. Our data suggest that selected AIRmax cellular and genetic immune mechanisms contribute to cartilage damage and arthritis severity, evidencing many targets for therapeutic actions.
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correa2018micebiomed Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Correa, Mara A.;Borrego, Andrea;Jensen, José R.;Cabrera, Wafa H. K.;Barros, Michele;Katz, Iana S. S.;Canhamero, Tatiane;Spadafora-Ferreira, Monica;Fernandes, Jussara G.;Starobinas, Nancy;Ribeiro, Orlando G.;Ibañez, Olga M.;Franco, Marcelo De;
Journal BioMed research international
Year 2018
DOI
DOI not found
URL
http://dx.doi.org/10.1155/2018/1267038
Keywords
Microbiology Biology (General) Medicine Immunologic diseases. Allergy public aspects of medicine

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