Interactions between the aging gut microbiome and common geriatric giants: polypharmacy, frailty and dementia.

Clicks: 426
ID: 97692
2020
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Ranked #2 of 150 articles by views in the journals of gerontology series a, biological sciences and medical sciences

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Abstract
The gut microbiome has pervasive bi-directional relationships with pharmacotherapy, chronic disease, and physical and cognitive function. We conducted a narrative review of the current literature to examine the relationships between the gut microbiome, medication use, sarcopenia and frailty, and cognitive impairment. Data from in vitro experiments, in vivo experiments in invertebrates and complex organisms, and humans indicate associations between the gut microbiome and geriatric syndromes. Better understanding of the direct and indirect roles of the microbiome may inform future prevention and management of geriatric syndromes.
Reference Key
gemikonakli2020interactionsthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Gemikonakli, Gizem;Mach, John;Hilmer, Sarah Nicole;
Journal the journals of gerontology series a, biological sciences and medical sciences
Year 2020
DOI
glaa047
URL
Keywords
microbiota polypharmacy pharmacology cognitive decline sarcopenia

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