Studying Peripheral T Cell Homeostasis in Mice: A Concise Technical Review.

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ID: 97490
2020
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Abstract
For several years, it was believed that the thymus was entirely responsible for maintaining T cell homeostasis. Today, it is well-known that homeostatic peripheral mechanisms are essential in order to maintain T cell numbers and diversity constant in the periphery. Naïve and memory T cells require continual access to self-peptide MHC class I and II molecules and/or cytokines to survive in the periphery. Under normal conditions, homeostatic resources are low, and lymphocytes undergo very slow proliferation and survive. Following T cell depletion, the bioavailability of homeostatic resources is significantly increased, and T cell proliferation is dramatically augmented. The development of lymphopenic mouse models has helped our current understanding of factors involved in the regulation of peripheral T cell homeostasis. In this minireview, we will give a brief overview about basic techniques used to study peripheral T cell homeostasis in mice.
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moutuou2020studyingmethods Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Moutuou, Moutuaata M;Gauthier, Simon-David;Chen, Nicolas;Leboeuf, Dominique;Guimond, Martin;
Journal methods in molecular biology (clifton, nj)
Year 2020
DOI
10.1007/978-1-0716-0266-9_21
URL
Keywords
homeostasis lymphocytes cd4 cd8 lymphopenia

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