Evaluation of New Bone Formation Using Autogenous Tooth Bone Graft Combined with Platelet-Rich Fibrin in Calvarial Defects.

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ID: 96906
2019
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Abstract
The purpose of the present study was to evaluate the contributions of autogenous tooth bone graft (ATBG) combined with platelet-rich fibrin (PRF) on new bone formation and bone morphogenetic protein (BMP)-2 in rabbit calvarial defects. Twelve male New Zealand rabbits were used in this study. Three circular bone defects were prepared in each rabbit with a drill. These defects were divided into 3 groups: control, treated with ATBG, and treated with ATBG+PRF. The animals were sacrificed at 28 days. Samples were evaluated by histomorphometric analyses and total augmented area, new bone area and bone density were calculated. In addition, expression of BMP-2 was determined by immunohistochemical staining. The total augmented area, new bone area and bone density were significantly greater in the ATBG group than in the control group (P <0.05). Also, these values were significantly higher in the ATBG+PRF group than the ATBG group (P <0.05). Test groups demonstrated significantly increased BMP-2 levels compared with the control group (P <0.05). The present study suggested that ATBG combined with PRF significantly increased the new bone formation and enhanced bone healing in cranial defects.
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kizildag2019evaluationthe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Kizildağ, Alper;Taşdemir, Ufuk;Arabaci, Taner;Özmen, Özlem;Kizildağ, Canan Aksu;Iyilikci, Berrin;
Journal the journal of craniofacial surgery
Year 2019
DOI
10.1097/SCS.0000000000005413
URL
Keywords
animal model cerebral palsy chorioamnionitis endotoxins inflammation

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