Photocatalytically Active Graphitic Carbon Nitride as an Effective and Safe 2D Material for In Vitro and In Vivo Photodynamic Therapy.

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ID: 96535
2020
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Abstract
Thanks to its photocatalytic property, graphitic carbon nitride (g-C N ) is a promising candidate in various applications including nanomedicine. However, studies focusing on the suitability of g-C N for cancer therapy are very limited and possible underlying molecular mechanisms are unknown. Here, it is demonstrated that photoexcitation of g-C N can be used effectively in photodynamic therapy, without using any other carrier or additional photosensitizer. Upon light exposure, g-C N treatment kills cancer cells, without the need of any other nanosystem or chemotherapeutic drug. The material is efficiently taken up by tumor cells in vitro. The transcriptome and proteome of g-C N and light treated cells show activation in pathways related to both oxidative stress, cell death, and apoptosis which strongly suggests that only when combined with light exposure, g-C N is able to kill cancer cells. Systemic administration of the mesoporous form results in elimination from urinary bladder without any systemic toxicity. Administration of the material significantly decreases tumor volume when combined with local light treatment. This study paves the way for the future use of not only g-C N but also other 2D nanomaterials in cancer therapy.
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taheri2020photocatalyticallysmall Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Taheri, Hadiseh;Unal, Mehmet Altay;Sevim, Melike;Gurcan, Cansu;Ekim, Okan;Ceylan, Ahmet;Syrgiannis, Zois;Christoforidis, Konstantinos C;Bosi, Susanna;Ozgenç, Ozge;Gómez, Manuel José;Turktas Erken, Mine;Soydal, Çigdem;Eroğlu, Zafer;Bitirim, Ceylan Verda;Cagin, Umut;Arı, Fikret;Ozen, Asuman;Kuçuk, Ozlem;Delogu, Lucia Gemma;Prato, Maurizio;Metin, Önder;Yilmazer, Açelya;
Journal Small (Weinheim an der Bergstrasse, Germany)
Year 2020
DOI
10.1002/smll.201904619
URL
Keywords
graphitic carbon nitride 2d materials photodynamic therapy antitumor activity omic approaches

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