Cytokines, cytokine gene polymorphisms and Helicobacter pylori infection: friend or foe?

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ID: 95865
2014
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Abstract
Helicobacter pylori (H. pylori) is a flagellated, spiral-shaped, microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50% of the human population. Infection is a risk factor for gastritis, ulcer disease and stomach cancer. Immunity against H. pylori is mainly related to Th1/Th17 skewing, and the activation of regulatory T cells is the main strategy used to limit inflammatory responses, which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases, including cancer. Furthermore, host genetic factors that affect cytokines may determine differences in the susceptibility to many diseases. In this review, we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to H. pylori and discuss how such polymorphisms may influence infection/disease outcomes.
Reference Key
figueiredo2014cytokinesworld Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Figueiredo, Camila A;Marques, Cintia Rodrigues;Costa, Ryan dos Santos;da Silva, Hugo Bernardino F;Alcantara-Neves, Neuza M;
Journal world journal of gastroenterology
Year 2014
DOI
10.3748/wjg.v20.i18.5235
URL
Keywords
cytokines immunity helicobacter pylori polymorphisms stomach cancer

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