Lipid Fraction Derived From MRI In- and Opposed-Phase Sequence as a Novel Biomarker for Predicting Survival Outcome of Glioma.

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ID: 93877
2020
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Abstract
Our study evaluated the capability of magnetic resonance imaging in- and opposed-phase (IOP) derived lipid fraction as a novel prognostic biomarker of survival outcome in glioma.We analyzed 46 histologically proven glioma (WHO grades II-IV) patients using standard 3T magnetic resonance imaging brain tumor protocol and IOP sequence. Lipid fraction was derived from the IOP sequence signal-loss ratio. The lipid fraction of solid nonenhancing region of glioma was analyzed, using a three-group analysis approach based on volume under surface of receiver-operating characteristics to stratify the prognostic factors into three groups of low, medium, and high lipid fraction. The survival outcome was evaluated, using Kaplan-Meier survival analysis and Cox regression model.Significant differences were seen between the three groups (low, medium, and high lipid fraction groups) stratified by the optimal cut-off point for overall survival (OS) (p ≤ 0.01) and time to progression (p ≤ 0.01) for solid nonenhancing region. The group with high lipid fraction had five times higher risk of poor survival and earlier time to progression compared to the low lipid fraction group. The OS plot stratified by lipid fraction also had a strong correlation with OS plot stratified by WHO grade (R = 0.61, p < 0.01), implying association to underlying histopathological changes.The lipid fraction of solid nonenhancing region showed potential for prognostication of glioma. This method will be a useful adjunct in imaging protocol for treatment stratification and as a prognostic tool in glioma patients.
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seow2020lipidacademic Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Seow, Pohchoo;Narayanan, Vairavan;Romelean, Ronie J;Wong, Jeannie Hsiu Ding;Win, Myint Tun;Chandran, Hari;Chinna, Karuthan;Rahmat, Kartini;Ramli, Norlisah;
Journal Academic radiology
Year 2020
DOI
S1076-6332(19)30232-6
URL
Keywords
stratification gliomas in- and opposed-phase sequence (iop) lipid fraction lipid quantification magnetic resonance spectroscopy (mrs) survival study three-group vus analysis

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