Mycotoxin Biosensor Based on Optical Planar Waveguide.

Clicks: 224
ID: 93796
2018
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Abstract
The research aim of this work is to develop a simple and highly sensitive optical biosensor for detection of mycotoxins. This sensor is built on a planar waveguide operating on the polarization interferometry principle, i.e., detecting a phase shift between p- and s-components of polarized light developed during the binding of analyte molecules. The operation of the proposed sensor is similar to that of a Mach⁻Zehnder interferometer, while its design is much simpler and it does not require splitting the waveguide into two arms. The refractive index sensitivity of the polarization interferometer sensor was in the range of 5200 radians per refractive index unit (RIU). Several tests were conducted to detect ochratoxin A (OTA) at different concentrations in direct immunoassay with specific antibodies immobilized in the sensing window. The lowest concentration of OTA of 0.01 ng/mL caused a phase shift of nearly one period. The results obtained prove high sensitivity of the sensors, which are capable of detecting even lower concentrations of mycotoxins at the ppt (part-per-trillion) level.
Reference Key
aljawdah2018mycotoxintoxins Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Al-Jawdah, Ali;Nabok, Alexei;Jarrah, Radhyah;Holloway, Alan;Tsargorodska, Anna;Takacs, Eszter;Szekacs, Andras;
Journal Toxins
Year 2018
DOI
E272
URL
http://www.mdpi.com/2072-6651/10/7/272
Keywords
mycotoxins planar waveguide polarization interferometer refractive index sensitivity optical biosensor

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