Typhoid toxin exhausts the RPA response to DNA replication stress driving senescence and Salmonella infection

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ID: 93686
2019
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Abstract
Salmonella Typhi produces the typhoid toxin, which damages host cell DNA. Here, Ibler et al. show that the toxin induces a non-canonical DNA damage response mediated by the RPA pathway that drives host cell senescence and facilitates infection.
Reference Key
ibler2019typhoidnature Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Ibler, Angela E. M.;ElGhazaly, Mohamed;Naylor, Kathryn L.;Bulgakova, Natalia A.;El-Khamisy, Sherif F.;Humphreys, Daniel;
Journal Nature communications
Year 2019
DOI
DOI not found
URL
http://link.springer.com/article/10.1038/s41467-019-12064-1
Keywords
Microbiology Pharmacy and materia medica Biology (General) Medicine Science Immunologic diseases. Allergy public aspects of medicine

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