Infection-based chemical screens uncover host-pathogen interactions.

Clicks: 359
ID: 93653
2020
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Ranked #1 of 4 articles by views in current opinion in microbiology

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Abstract
Bacterial pathogens must resist host innate immunity to cause disease. While Gram-negative bacteria have a protective outer membrane, this membrane is subject to host-induced damage that makes these pathogens vulnerable. We developed a high content screening platform that identifies compounds that cause the killing of the bacterial pathogen Salmonella enterica in macrophages. This platform enables the rapid discovery of compounds that work in concert with the macrophage to prevent pathogen survival, as most hit compounds are not active in standard microbiological media and are not pro-drugs. We describe within the platform and the compounds it has found, and consider how they may help us discover new ways to fight infection.
Reference Key
detweiler2020infectionbasedcurrent Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Detweiler, Corrella S;
Journal current opinion in microbiology
Year 2020
DOI
S1369-5274(20)30003-5
URL
Keywords
Antimicrobial activity probiotics chickens dna sequencing lactobacillus

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