Designing Chimeric Molecules for Drug Discovery by Leveraging Chemical Biology.

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ID: 92794
2020
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Abstract
After the first seed concept introduced in the 18th century, different disciplines have attributed different names to dual-functional molecules depending on their application, including bioconjugates, bifunctional compounds, multi targeting molecules, chimeras, hybrids, engineered compounds. However, these engineered constructs share a general structure: a first component which targets a specific cell and a second component that exerts the pharmacological activity. A stable or cleavable linker connects the two modules of a chimera. Herein, we discuss the recent advances in the rapidly expanding field of chimeric molecules leveraging chemical biology concepts. This perspective is focused on bifunctional compounds in which one component is a lead compound or a drug. In details, we discuss chemical features of chimeric molecules, their use for targeted delivery, and for target engagement studies.
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borsari2020designingjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Borsari, Chiara;Trader, Darci J;Tait, Annalisa;Costi, Maria Paola;
Journal Journal of medicinal chemistry
Year 2020
DOI
10.1021/acs.jmedchem.9b01456
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Keywords Keywords not found

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