EGF-containing Membrane-bound Mucins: a hidden ErbB2 targeting pathway?

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ID: 92789
2020
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Abstract
Membrane-bound mucins belong to a heterogeneous family of large O-glycoproteins involved in numerous cancers and inflammatory diseases of the epithelium. Some of them are also involved in protein-protein interactions (PPI), with receptor tyrosine kinase (RTK) ErbB2, and fundamental and clinical data showed that these complexes have a detrimental impact on cancer outcome thus raising interest for therapeutic targeting. This paper aims at demonstrating that MUC3, MUC4, MUC12, MUC13 and MUC17 came from a common evolutionary origin and share a common structural organization with EGF-like and SEA domains. Theoretical structure-function relationship analysis of the conserved domains were performed indicating that the studied membrane-bound mucins share common biological properties along with potential specific functions. Finally, the potential druggability of these complexes were discussed revealing ErbB2-related pathways of cell signaling to be targeted.
Reference Key
liberelle2020egfcontainingjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Liberelle, Maxime;Jonckheere, Nicolas;Melnyk, Patricia;Van Seuningen, Isabelle;Lebegue, Nicolas;
Journal Journal of medicinal chemistry
Year 2020
DOI
10.1021/acs.jmedchem.9b02001
URL
Keywords Keywords not found

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