Sarco/endoplasmic reticulum calcium ATPase inhibitors: Beyond anticancer perspective.

Clicks: 191
ID: 92788
2020
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Abstract
The sarco/endoplasmic reticulum calcium ATPase (SERCA), which plays a key role in the maintenance of Ca2+ ion homeostasis, is an extensively studied enzyme, the inhibition of which has a considerable impact on cell life and death decision. To date, several SERCA inhibitors have been thoroughly studied and the most notable one, a derivative of the sesquiterpene lactone thapsigargin, is gradually approaching a clinical application. Meanwhile, new compounds with SERCA-inhibiting properties of natural, synthetic or semisynthetic origin are being discovered and/or developed; some of these might be also suitable for the development of new drugs with improved performance. This review brings an up-to-date comprehensive overview of recently discovered compounds with the potential of SERCA inhibition, discusses their mechanism of action, and it highlights their potential clinical applications, such as cancer treatment.
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peterkova2020sarcoendoplasmicjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Peterkova, Lucie;Kmoníčková, Eva;Ruml, Tomáš;Rimpelova, Silvie;
Journal Journal of medicinal chemistry
Year 2020
DOI
10.1021/acs.jmedchem.9b01509
URL
Keywords Keywords not found

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