Downregulation of GPSM2 is associated with primary resistance to paclitaxel in breast cancer.

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ID: 91977
2020
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Abstract
Paclitaxel is one of the most effective chemotherapy drugs for breast cancer worldwide but 20‑30% patients show primary resistance to the drug. Screening and identification of markers that facilitate effective and rapid prediction of sensitivity to paclitaxel is therefore an urgent medical requirement. In the present study, G protein signaling modulator 2 (GPSM2) mRNA levels were significantly associated with taxane sensitivity in experiments based on the Gene Expression Omnibus (GEO) online database. Immunohistochemical analysis consistently revealed a significant association of GPSM2 protein levels with paclitaxel sensitivity in breast cancer patients. Knockdown of GPSM2 reduced the sensitivity of breast cancer cells to paclitaxel via regulation of the cell cycle. Animal experiments further corroborated our in vitro findings. These results suggest that GPSM2 plays an important role in breast cancer resistance, supporting its utility as a potential target for improving drug susceptibility in patients as well as a marker of paclitaxel sensitivity.
Reference Key
zhang2020downregulationoncology Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Zhang, Zhe;Li, Zhi;Deng, Mingming;Liu, Bofang;Xin, Xing;Zhao, Zhenkun;Zhang, Ye;Lv, Qingjie;
Journal oncology reports
Year 2020
DOI
10.3892/or.2020.7471
URL
Keywords
Breast cancer stemness hippo/yap lats2 mir-520b

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