Obesogenic effects of chlorpyrifos and its metabolites during the differentiation of 3T3-L1 preadipocytes.

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ID: 91658
2020
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Ranked #25 of 54 articles by views in food and chemical toxicology : an international journal published for the british industrial biological research association

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Abstract
Chlorpyrifos (CPF) is an organophosphorus pesticide widely and extensively used in agriculture in more than one hundred countries and found ubiquitously in the environment. The present study was aimed at providing a better understanding of the obesogenic potential of CPF and its metabolites, as well as to evaluate their effects on the adipocyte differentiation process. For it, during the initial differentiation process, 3T3-L1 mouse preadipocytes were exposed to different concentrations of CPF, CPF-oxon (CPO), or 3,5,6-trichloropyridinol (TCP), which did not affect cell survival. Results showed how CPF and, to a lesser extent, its metabolite TCP, had a positive metabolic influence over the adipogenic process by fostering an increase in the number of differentiated 3T3-L1 preadipocytes, and by enhancing the capacity to store lipid droplets. These processes seem to occur through the upregulation of the transcription factors CCAAT/enhancer-binding protein α (C/EBPα) and peroxisome proliferator-activated receptor γ (PPARγ), which are related to a significant higher expression of the fatty acid-binding protein 4 (FABP4) adipokine. Based on this finding, CPF exposure could be one of the many factors that contributes to the worldwide increase in the incidence of obesity. However, additional investigations are clearly needed.
Reference Key
blanco2020obesogenicfood Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Blanco, Jordi;Guardia-Escote, Laia;Mulero, Miquel;Basaure, Pia;Biosca-Brull, Judit;Cabré, Maria;Colomina, Maria Teresa;Domingo, José L;Sánchez, Domènec J;
Journal food and chemical toxicology : an international journal published for the british industrial biological research association
Year 2020
DOI
S0278-6915(20)30059-4
URL
Keywords
chlorpyrifos adipogenesis peroxisome proliferator-activated receptor γ obesogen

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