In vitro benchmarking of NF-κB inhibitors.

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ID: 91404
2020
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Ranked #12 of 103 articles by views in European journal of pharmacology

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Abstract
Dysregulated activity of the transcription factors of the nuclear factor κb (NF-κB) family has been implicated in numerous cancer types, inflammatory diseases, autoimmune disease, and other disorders. As such, selective NF-κB pathway inhibition is an attractive target to researchers for preclinical and clinical drug development. A plethora of commercially and clinically available inhibitors claim to be NF-κB specific; however, such claims of specificity are rarely quantitative or benchmarked, making the biomedical literature difficult to contextualize. This imprecision is worsened because some NF-κB reporter systems have low signal-to-noise ratios. Herein, we use a robust, defined, commercially available reporter system to benchmark NF-κB agonists and antagonists for the field. We also functionally characterize a RELA fusion-positive ependymoma cell culture with validated NF-κB inhibitor compounds.
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harrold2020ineuropean Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Alexandria P Harrold, Megan M Cleary, Narendra Bharathy, Melvin Lathara, Noah E Berlow, Nicholas K Foreman, Andrew M Donson, Vladimir Amani, William J Zuercher, Charles Keller
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Journal European journal of pharmacology
Year 2020
DOI
S0014-2999(20)30073-X
URL
Keywords
nf-κb ependymoma rela

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