Immunoglobulin G N-Glycan Analysis by Ultra-Performance Liquid Chromatography.

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ID: 91353
2020
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Abstract
Glycomics is a new subspecialty in omics system research that offers significant potential in discovering next-generation biomarkers for disease susceptibility, drug target discovery, and precision medicine. Alternative IgG N-glycans have been reported in several common chronic diseases and suggested to have great potential in clinical applications (i.e., biomarkers for diagnosis and prediction of diseases). IgG N-glycans are widely characterized using the method of hydrophilic interaction chromatography (HILIC) ultra-performance liquid chromatography (UPLC). UPLC is a stable detection technology with good reproducibility and high relative quantitative accuracy. In addition, the structure of IgG N-glycan is clearly separated, and glycan composition and relative abundance in plasma are characterized.
Reference Key
liu2020immunoglobulinjournal Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Liu, Di;Xu, Xizhu;Li, Yuejin;Zhang, Jie;Zhang, Xiaoyu;Li, Qihuan;Hou, Haifeng;Li, Dong;Wang, Wei;Wang, Youxin;
Journal Journal of visualized experiments : JoVE
Year 2020
DOI
10.3791/60104
URL
Keywords
Children extrahepatic portal venous obstruction portal cavernoma rex shunt

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