Plasma pharmacokinetics of bedaquiline administered by nasogastric tube in an intensive care unit.

Clicks: 494
ID: 91124
2020
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Ranked #1 of 14 articles by views in the international journal of tuberculosis and lung disease : the official journal of the international union against tuberculosis and lung disease

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Abstract
We present the case of a 21-year-old man admitted to the intensive care unit with multi-organ failure due to multidrug-resistant tuberculosis (TB). TB treatment initially comprised moxifloxacin, ethambutol, linezolid and amikacin administered intravenously. Due to suspected moxifloxacin-induced liver injury, we stopped all fluoroquinolones and switched to bedaquiline (BDQ), which is only available in tablets for oral administration. Since our patient had to be fed through a nasogastric tube (NGT), BDQ was administered after being crushed and dissolved in water; drug pharmacokinetics were studied using repeated blood sampling. Therapeutic drug monitoring showed that BDQ was detectable in blood plasma with a trough concentration above the supposed efficacy threshold, suggesting that this molecule could be administered through NGT.
Reference Key
dang2020plasmathe Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Dang, E;Sayagh, F;Lê, M P;Neuville, M;Sinnah, F;Timsit, J-F;Peytavin, G;
Journal the international journal of tuberculosis and lung disease : the official journal of the international union against tuberculosis and lung disease
Year 2020
DOI
10.5588/ijtld.19.0221
URL
Keywords
taxonomy whole genome sequencing non-tuberculous mycobacteria (ntm) mycobacterium kansasii complex mycobacterium ostraviense sp. nov.

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