Marcanine G, a new cytotoxic 1-azaanthraquinone from the stem bark of Goniothalamus marcanii Craib.

Clicks: 234
ID: 90160
2018
Article Quality & Performance Metrics
Overall Quality
Not rated
Combines reader engagement with the AI quality analysis. This article has not been analysed, so there is no overall score — reader engagement is measured and shown alongside.
AI Quality Assessment
Not analyzed
Readership in this journal
Steady

Ranked #53 of 83 articles by views in Natural product research

Most read Least read

Bar heights use a square-root scale.

Mint this article as an NFT
Not yet minted

Create a permanent, verifiable on-chain record of this article on the Scimatic Network. The NFT is held in your Journament account, and you can withdraw it to your own wallet at any time.

5 SUSD one-off · no wallet required
Sign in to mint
Abstract
The ethanolic extract from the stem bark of Goniothalamus marcanii Craib was shown in preliminary brine shrimp lethality data having good cytotoxic activity. Further bioassay guided isolation was done by means of solvent partition, chromatography and precipitation to provide four isolated compounds: a novel compound 1 with the core structure of 1-azaanthraquinone moiety referred as marcanine G; as well as compounds 2-4 with known aristolactam structures namely, piperolactam C, cepharanone B and taliscanine. These compounds were characterised by spectroscopic techniques. The assessment of cytotoxicity was established on an SRB assay using doxorubicin as a positive control. Marcanine G (1) was considered the most active compound indicating the IC values of 14.87 and 15.18 μM against human lung cancer cells (A549) and human breast cancer cells (MCF7), respectively. However, 2 showed mild activity with the IC values of 83.72 and 82.32 μM against A549 and MCF7 cells, respectively.
Reference Key
thanuphol2018marcaninenatural Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors Thanuphol, Pongpol;Asami, Yukihiro;Shiomi, Kazuro;Wongnoppavich, Ariyaphong;Tuchinda, Patoomratana;Soonthornchareonnon, Noppamas;
Journal Natural product research
Year 2018
DOI
10.1080/14786419.2017.1396588
URL
Keywords
Cytotoxicity 1-azaanthraquinones goniothalamus marcanii marcanine g

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.