Maternal Photoperiodic Programming: Melatonin and Seasonal Synchronization Before Birth.

Clicks: 267
ID: 90061
2019
Article Quality & Performance Metrics
Overall Quality Improving Quality
0.0 /100
Combines engagement data with AI-assessed academic quality
AI Quality Assessment
Not analyzed
Abstract
This mini-review considers the phenomenon of maternal photoperiodic programming (MPP). In order to match neonatal development to environmental conditions at the time of birth, mammals use melatonin produced by the maternal pineal gland as a transplacental signal representing ambient photoperiod. Melatonin acts via receptors in the fetal pituitary gland, exerting actions on the developing medio-basal hypothalamus. Within this structure, a central role for specialized ependymal cells known as tanycytes has emerged, linking melatonin to control of hypothalamic thyroid metabolism and in turn to pup development. This review summarizes current knowledge of this programming mechanism, and its relevance in an eco-evolutionary context. Maternal photoperiodic programming emerges as a useful paradigm for understanding how programing of hypothalamic function leads to life-long effects on growth, reproduction, health and disease in mammals, including humans.
Reference Key
van-dalum2019maternalfrontiers Use this key to autocite in the manuscript while using SciMatic Manuscript Manager or Thesis Manager
Authors van Dalum, Jayme;Melum, Vebjørn J;Wood, Shona H;Hazlerigg, David G;
Journal Frontiers in endocrinology
Year 2019
DOI
10.3389/fendo.2019.00901
URL
Keywords
fetal programming melatonin deiodinase pars tuberalis photoperiodic history tanycyte thyroid hormone (t3) thyrotropin (tsh—thyroid-stimulating hormone)

Citations

No citations found. To add a citation, contact the admin at info@scimatic.org

Comments

No comments yet. Be the first to comment on this article.